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Contraindicated (1)pentobarbital will lessen the level or impact of dienogest/estradiol valerate by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Ladies should not decide on estradiol valerate/dienogest as their contraceptive when employing robust CYP3A4 inducers due to probable lessen in contraceptive efficacy.pentobarb